Manuel*, age 55

Living with Type II Diabetes

"I've heard some statins can raise blood sugar levels. But my doctor told me ZYPITAMAG has been shown not to change blood sugar levels significantly compared with Lipitor^® (atorvastatin). So I decided to give ZYPITAMAG a try."

The 2018 ACC/AHA Multisociety Guidelines on the Management of Blood Cholesterol recommend that individuals living with diabetes mellitus who are 40-75 years of age should initiate a moderate intensity statin.¹ ZYPITAMAG (pitavastatin magnesium) is a moderate intensity-statin and is available in doses of 2 and 4 mg.²

Pitavastatin has demonstrated effective LDL cholesterol lowering of up to 41% in individuals living with type 2 diabetes mellitus, with 4 mg pitavastatin being comparable with commonly prescribed 20 mg Lipitor^® (atorvastatin).²

Interestingly, in the same study, pitavastatin demonstrated a non-significant change in blood glucose levels compared to baseline. This was in contrast to Lipitor^® (atorvastatin), which demonstrated a significant increase in blood glucose levels compared to baseline.²

If you have high cholesterol and type 2 diabetes, ask your doctor if ZYPITAMAG is right for you!

Lipitor^® is a trademark of Pfizer Inc.

¹ Grundy SM et al. J Am Coll Cardiol. 2018;Nov 10:[Epub ahead of print]

² ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

Doug*, age 70

Is over age 65

"I do what I can to stay active, but my cholesterol levels are still high. My doctor told me a healthy diet and exercise aren't always enough, and he started me on treatment with ZYPITAMAG."

Are you over the age of 65? If you are like most Americans over the age of 65 who have high cholesterol, you may be taking other medications along with your statin therapy.

Some statins may have potential drug interactions with certain medications. The unique design of pitavastatin allows this statin to circumvent the common pathways by which drugs are metabolized, thereby reducing the likelihood for certain drug interactions.¹

Pitavastatin has been shown to effectively lower LDL cholesterol in persons over the age of 65 with high cholesterol.¹ In this study, pitavastatin provides superior LDL cholesterol lowering to Pravachol^® (pravastatin). Both pitavastatin and pravastatin have shown comparable tolerability in this patient population.¹

If you have high cholesterol and are over the age of 65, ask your doctor about ZYPITAMAG!

Pravachol^® is a registered trademark of Bristol-Myers Squibb Company

¹ ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

Mel*, age 40

Is of Asian descent

"I have high cholesterol. My doctor said the body processes some statins differently based on ethnic background—especially for people of Asian descent. She suggested I start taking ZYPITAMAG at the normal starting dose. So, unlike with Crestor^® (rosuvastatin), I can get the full dosing range of ZYPITAMAG."

The level of statin in your bloodstream can vary depending on several factors, one of these factors being race, which affects the way our bodies process the medications we take. In people of Asian descent, the drug metabolism pathways can sometimes lead to increased accumulation of statins.¹

The new 2018 ACC/AHA Multisociety Guidelines on the Management of Blood Cholesterol recommends that extra diligence be taken with regards to statin safety in persons of Asian descent.²

Unlike Crestor^® (rosuvastatin), there are no recommended dose restrictions for people of Asian descent who take ZYPITAMAG (pitavastatin).^3,4 This means that if you require a statin, you can receive the full dosing range of ZYPITAMAG.

If you are of Asian descent and have high cholesterol ask your doctor if ZYPITAMAG is right for you!

Crestor^® is a trademark of the AstraZeneca group of countries

¹ Naito R et al. J Atheroscler Thromb. 2017;24(1):19-25

² Grundy SM et al. J Am Coll Cardiol. 2018;Nov 10:[Epub ahead of print]

³ Crestor^® (rosuvastatin) Prescribing Information. AstraZeneca Pharmaceuticals LP, Wilmington, DE; August 2017

⁴ ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

Lawrence*, age 64

Takes other prescription medicines

"I take calcium channel blockers (CCBs) for my high blood pressure, and I'm worried about drug interactions. My doctor said ZYPITAMAG can be taken with CCBs. So I've been taking ZYPITAMAG for 3 months now."

Are you taking other medications along with your statin therapy? Some statins may interact with certain other medications.

ZYPITAMAG (pitavastatin) is a next generation statin that effectively lowers LDL-C by up to 45%.¹ ZYPITAMAG is designed to circumvent the common pathway through which most statins are metabolized thereby reducing the potential for certain drug interactions.¹

If you are taking multiple medications and have high cholesterol, ask your doctor about ZYPITAMAG!

¹ ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

Linda*, age 32

Has 2 or more risk factors for cardiovascular disease

"I've been a smoker for over 10 years, and I really don't exercise. Heart disease runs in my family, so I was worried about my high cholesterol. I talked with my doctor, and she gave me samples of ZYPITAMAG."

Some risk factors for coronary heart disease are modifiable, whereas other factors are not. According to the World Heart Federation, some modifiable risk factors include¹:

• Physical inactivity
• Tobacco use
• Eating a diet high in saturated and trans fats
• Suboptimal blood lipids (fats)
  • Increased LDL cholesterol (bad cholesterol)
  • Low HDL cholesterol (good cholesterol)
  • Increased triglycerides (TG)
• High blood pressure (hypertension)
• Obesity

Some non-modifiable risk factors include¹:

• Family history of cardiovascular disease - if a first-degree male relative has suffered a heart attack before the age of 55, or if a first-degree female relative has suffered one before the age of 65 you are at grater risk of developing heart disease
• Diabetes - having diabetes increases your risk of heart disease
• Age - simply getting older increases your risk for cardiovascular disease
• Ethnicity - people with African and Asian ancestry are at higher risks of developing cardiovascular disease

Pitavastatin is a next generation statin that is used to treat dyslipidemia, which is one of the modifiable risk factors for coronary heart disease. Pitavastatin reduces LDL cholesterol (bad cholesterol) by up to 45%.²

Pitavastatin has been studied in people with high cholesterol who also have 2 or more risk factors^✝ for coronary heart disease.² In this study, pitavastatin (2 mg, 4 mg) demonstrated comparable efficacy in LDL cholesterol lowering to commonly prescribed strengths of Zocor^® (simvastatin, 20 mg, 40 mg, respectively).²

ZYPITAMAG (pitavastatin) is designed to circumvent the common pathway through which most statins are metabolized thereby reducing the potential for certain drug interactions. Importantly, unlike some statins, such as Zocor^® (simvastatin), ZYPITAMAG does not require a dose limitation for medications such as diltiazem, a calcium channel blockers (CCBs) and no restrictions with consumption of products such as grapefruit juice.^2,3

If you have dyslipidemia and 2 or more risk factors for coronary heart disease ask your doctor about ZYPITAMAG!

¹ https://www.world-heart-federation.org/resources/risk-factors/

² ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

³ Zocor^® (simvastatin) Prescribing Information. Whitehouse Station, NJ: Merck & Co., Inc: March 2015

^✝ Cardiovascular risk factors were considered to be cigarette smoking, blood pressure of 140/90 mmHg or above or receiving antihypertensive therapy, a high-density lipoprotein cholesterol (HDL-C) concentration of 40 mg/dL or below, and a family history of coronary heart disease in a male or female first-degree relative below 55 or below 65 years of age, respectively; age above 45 years in men or above 55 years in women. An HDL-C concentration above 60 mg/dL was considered to offset one risk factor. (Eriksson M et al. Adv Ther. 2011;28(9):811-823)

Anthony*, age 20

Takes antiretroviral therapy (ART)

"I'm a person living with HIV and am on ART. When I found out I had high cholesterol, my doctor told me some statins can't be taken with ART, but not ZYPITAMAG. So he recommended I try ZYPITAMAG to manage my high cholesterol."

According to the 2018 ACC/AHA Multisociety Guidelines on the Management of Blood Cholesterol, chronic inflammatory diseases, including HIV infection, are risk enhancers for atherosclerotic cardiovascular disease.¹

Statins may have potentially serious drug interactions with HIV-protease inhibitors, resulting in contraindications or dose limitations.² The design of pitavastatin allows this statin to circumvent the common pathways used for drug metabolism by certain antiretroviral therapies.

Pitavastatin effectively lowers LDL-C by up to 45% with no dose limitations required when prescribed in combination with HIV protease inhibitors, such as atazanavir, darunavir/ritonavir, lopinavir/ritonavir.^2,3

Now available on ADAP!

¹ Grundy SM et al. J Am Coll Cardiol. 2018;Nov 10:[Epub ahead of print]

² ZYPITAMAG™ [prescribing information]. Ahmedabad, India: Cadila Healthcare Ltd; August 2018

³ FDA Drug Safety Communication: Interactions between certain HIV or hepatitis C drugs and cholesterol-lowering statin drugs can increase the risk of muscle injury. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-interactions-between-certain-hiv-or-hepatitis-c-drugs-and-cholesterol. Accessed May 9, 2019