* Average percent change in LDL cholesterol after 12 weeks taking pitavastatin or pravastatin.
Pitavastatin (2 mg, 4 mg) reduced LDL-C better than Pravachol® (20 mg, 40 mg, respectively) in people 65 years or older.*†
With Pravastatin, there is a drug interaction with Nexletol® (bempedoic acid) tablets, another cholesterol lowering drug, which can increase the risk of side effects, like muscle pain. Pravastatin greater than 40 mg should not be used in combination with Nexletol.1
Like pravastatin, you can continue to drink your grapefruit juice while on Zypitamag. This is not the case for many other statins like atorvastatin (Lipitor®), simvastatin (Zocor®), and lovastatin (Mevacor®).
Call 1-800-286-6781 to learn more
Download Discussion Guide to bring to your next appointment.
Pravachol is a registered trademark of Bristol-Myers Squibb Company.
Lipitor is a registered trademark of Pfizer, Inc.
Zocor is a registered trademark of Merck & Co., Inc.
Mevacor is a registered trademark of Merck Sharp & Dohme Corpe, a subsidiary of Merck & Co. Inc.
† Study 306: 12 week, randomized, multicenter, double-blind, double-dummy, active-controlled, non-inferiority (NI) study. NI was met if the lower bound of the 95% Cl for the mean treatment difference was greater than -6% for the mean percent change in LDL-C.
* Pitavastatin was not studied against Pravastatin 80 mg.
* Average percent change in LDL cholesterol after 12 weeks taking pitavastatin or atorvastatin.
A clinical study compared how pitavastatin and Lipitor compared in people who had high cholesterol*†. In terms of ability to lower bad cholesterol (LDL-C), the study showed that:
Zypitamag is processed differently by most statinsⱡ, by a process called glucuronidation. This is different from Lipitor® (atorvastatin) which is mainly processed by an enzyme called CYP3A4, part of the CYP450 family of enzymes. The CYP450 family of enzymes is responsible for 70-80% of all drug-metabolisms.1 Because of this key difference, Zypitamag has a reduce potential for interactions with foods and many commonly prescribed medications.
Unlike Lipitor®, Zypitamag has no interaction with grapefruit juice, and therefore, when taking Zypitamag you can continue to enjoy your grapefruit juice!
Increases in blood sugar levels have been seen with statin medications, including Zypitamag. In a clinical study, 4 mg pitavastatin was compared to 20 mg atorvastatin in people who had type 2 diabetes.2 In this study, there was no clinically significant difference in terms of reduction in bad cholesterol (LDL-C). However, when looking at changes in blood glucose levels of patients taking pitavastatin, there was a non-significant change in blood glucose levels compared to the patient's baseline blood glucose levels. In contrast, atorvastatin did significant increase blood glucose levels compared to baseline. If you have Type 2 Diabetes, ask your doctor if Zypitamag may be the right statin for you!
Unlike Lipitor®, Zypitamag has no dose restrictions or limitations when used with certain antifungals such as itraconazole.
Unlike Lipitor®, Zypitamag can be used together with certain antiretroviral therapies (ARTs) such as lopinavir and ritonavir.
Call 1-800-286-6781 to learn more
Download Discussion Guide to bring to your next appointment.
† Study 301: 12 week, randomized, multicenter, double-blind, double-dummy, active-controlled, non-inferiority (NI) study. NI was met if the lower bound of the 95% Cl for the mean treatment difference was greater than -6% for the mean percent change in LDL-C.
* Pitavastatin was not studied against Atorvastatin 40 mg and 80 mg doses.
ⱡ The main mechanism of Zypitamag metabolism is conjugation with glucuronic acid through liver glucuronosyltransferases leading to the formation of pitavastatin lactone. Pitavastatin is marginally metabolized by CYP2C9 and to a lesser extent by CYP2C8.
1 https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450
2 Gumprecht et al. Diabetes Obesity and Metabolism. 2011;13:1047-1055
Lipitor is a registered trademark of Pfizer, Inc.
With 4 mg Zypitamag you can expect up to a 44% reduction in bad cholesterol (LDL-C) and a 7% increase in good cholesterol (HDL-C). Unfortunately, at this time there had been no head-to-head studies to compare Zypitamag with rosuvastatin (Crestor®).
Zypitamag is processed differently by most statinsⱡ, by a process called glucuronidation. This is different from Crestor® (rosuvastatin) which is mainly processed by an enzyme called CYP2C9, part of the CYP450 family of enzymes. The CYP450 family of enzymes is responsible for 70-80% of all drug-metabolisms.1 Because of this key difference, Zypitamag has a reduce potential for interactions with foods and many commonly prescribed medications.
Unlike Crestor®, there are no recommended dose restrictions for people of Asian descent who take Zypitamag.
Unlike Crestor®, Zypitamag can be used together with certain antiretroviral therapies (ARTs) such as lopinavir and ritonavir without any dose limitations or restrictions.
Call 1-800-286-6781 to learn more
Download Discussion Guide to bring to your next appointment.
ⱡ The main mechanism of Zypitamag metabolism is conjugation with glucuronic acid through liver glucuronosyltransferases leading to the formation of pitavastatin lactone. Pitavastatin is marginally metabolized by CYP2C9 and to a lesser extent by CYP2C8.
1 https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450
Crestor is a registered trademark of the AstraZeneca group of companies.
* Average percent change in LDL cholesterol after 12 weeks taking pitavastatin or simvastatin.
Pitavastatin 4 mg has also been compared to simvastatin 40 mg, and showing a similar reduction in lowering bad cholesterol (LDL-C); 44% vs. 43%, respectively*†
Zypitamag is processed differently by most statinsⱡ, by a process called glucuronidation. This is different from Zocor® (simvastatin) which is mainly processed by an enzyme called CYP3A4, part of the CYP450 family of enzymes. The CYP450 family of enzymes is responsible for 70-80% of all drug-metabolisms.1 Because of this key difference, Zypitamag has a reduce potential for interactions with foods and many commonly prescribed medications.
Unlike Zocor®, Zypitamag has no interaction with grapefruit juice, and therefore, when taking Zypitamag you can continue to enjoy your grapefruit juice!
Unlike Zocor®, Zypitamag does not require a dose limitation for calcium channel blockers (CCBs) such as amlodipine and diltiazem.
Unlike Zocor®, Zypitamag has no effect on prothrombin time (PT) or international normalized ratio (INR) when co-administered with warfarin. However, PT and INR should still be routinely monitored by your doctor.
Unlike Zocor®, Zypitamag can be used in combination with antiretroviral therapies (ARTs) such as atazanavir, darunavir/ritonavir, and lopinavir/ritonavir.
Unlike Zocor®, Zypitamag has no dose restrictions or limitations when used with certain antifungals such as itraconazole.
Call 1-800-286-6781 to learn more
Download Discussion Guide to bring to your next appointment.
Zocor is a registered trademark of Merck & Co., Inc.
† Study 302: 12 week, randomized, multicenter, double-blind, double-dummy, active-controlled, non-inferiority (NI) study. NI was met if the lower bound of the 95% Cl for the mean treatment difference was greater than -6% for the mean percent change in LDL-C.
ⱡ The main mechanism of Zypitamag metabolism is conjugation with glucuronic acid through liver glucuronosyltransferases leading to the formation of pitavastatin lactone. Pitavastatin is marginally metabolized by CYP2C9 and to a lesser extent by CYP2C8.
With 4 mg Zypitamag you can expect up to a 44% reduction in bad cholesterol (LDL-C) and a 7% increase in good cholesterol (HDL-C). Unfortunately, at this time there had been no head-to-head studies to compare Zypitamag with lovastatin (Mevacor®).
Zypitamag is processed differently by most statinsⱡ, by a process called glucuronidation. This is different from Mevacor® (lovastatin) which is mainly processed by an enzyme called CYP3A4, part of the CYP450 family of enzymes. The CYP450 family of enzymes is responsible for 70-80% of all drug-metabolisms.1 Because of this key difference, Zypitamag has a reduce potential for interactions with foods and many commonly prescribed medications.
Unlike Mevacor®, Zypitamag has no interaction with grapefruit juice, and therefore, when taking Zypitamag you can continue to enjoy your grapefruit juice!
Unlike Mevacor®, Zypitamag has no effect on prothrombin time (PT) or international normalized ratio (INR) when co-administered with warfarin. However, PT and INR should still be routinely monitored by your doctor.
Unlike Mevacor®, Zypitamag can be used in combination with antiretroviral therapies (ARTs) such as atazanavir, darunavir/ritonavir, and lopinavir/ritonavir.
Unlike Mevacor®, Zypitamag has no dose restrictions or limitations when use with certain antifungals such as itraconazole.
Call 1-800-286-6781 to learn more
Download Discussion Guide to bring to your next appointment.
ⱡ The main mechanism of Zypitamag metabolism is conjugation with glucuronic acid through liver glucuronosyltransferases leading to the formation of pitavastatin lactone. Pitavastatin is marginally metabolized by CYP2C9 and to a lesser extent by CYP2C8.
1 https://ghr.nlm.nih.gov/primer/genefamily/cytochromep450
Mevacor is a registered trademark of Merck Sharp & Dohme Corpe, a subsidiary of Merck & Co. Inc
Questions to ask your healthcare provider
Call us at 1-800-286-6781 to learn how to get a prescription
Who should NOT take ZYPITAMAG?
ZYPITAMAG is not right for everyone. Do not take ZYPITAMAG if:
What is the most important information I should know and talk to my doctor about?
What are the most common side effects of ZYPITAMAG?
The most common side effects of ZYPITAMAG in clinical studies were:
This is not a complete list of side effects. Talk to your healthcare provider for more information.
You are encouraged to report negative side effects of all drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.
How should I store and take ZYPITAMAG?
Other important information I should know about ZYPITAMAG.
For additional information, please see the full Prescribing Information.