Considering Zypitamag™

Considering ZYPITAMAG™ (pitavastatin) tablets

Compare ZYPITAMAG with your current statin.

 

Pravachol®

(pravastatin)

Results

Pitavastatin (1 mg, 2 mg, 4 mg) reduced LDL-C better than Pravachol® (10 mg, 20 mg, 40 mg, respectively) in people 65 years or older.

Other Key Points

Rates of side effects were similar between pitavastatin and Pravachol®.

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Lipitor®

(atorvastatin)

Results

Pitavastatin (2 mg, 4 mg) has demonstrated comparable efficacy in lipid lowering to atorvastatin (10 mg, 20 mg, respectively).

Other Key Points

ZYPITAMAG may be less likely than Lipitor to cause certain drug interactions because it is processed differently in the body.

Unlike Lipitor®, ZYPITAMAG has no dose restrictions or limitations when used with certain antifungals such as itraconazole.

Unlike Lipitor®, ZYPITAMAG can be used together with certain antiretroviral therapies (ARTs) such as atazanavir, darunavir/ritonavir, and lopinavir/ritonavir.

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Crestor®

(rosuvastatin)

Results

No trials comparing Crestor® and ZYPITAMAG are available at this time

Other Key Points

Unlike Crestor®, ZYPITAMAG can be used together with certain antiretroviral therapies (ARTs) such as atazanvir/ritonavir and lopinavir/ritonavir without any dose limitations or restrictions.

Unlike Crestor®, there are no recommended dose restrictions for people of Asian descent who take ZYPITAMAG.

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Zocor®

(simvastatin)

Results

Pitavastatin (2 mg, 4 mg) has similar results in lowering lipid numbers to simvastatin (20 mg, 40 mg, respectively).

Other Key Points

ZYPITAMAG may be less likely than Zocor® to cause certain drug interactions.

Unlike Zocor®, ZYPITAMAG has no effect on prothrombin time (PT) or international normalized ratio (INR) when co-administered with warfarin. However, PT and INR should still be routinely monitored by your doctor.

Unlike Zocor®, ZYPITAMAG can be used in combination with antiretroviral therapies (ARTs) such as atazanavir, darunavir/ritonavir, and lopinavir/ritonavir.

Unlike Zocor®, ZYPITAMAG does not require a dose limitation for calcium channel blockers (CCBs) such as amlodipine and diltiazem.

Unlike Zocor®, ZYPITAMAG doesn't require restrictions for grapefruit products.

Unlike Zocor®, ZYPITAMAG has no dose restrictions or limitations when used with certain antifungals such as itraconazole.

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Mevacor®

(lovastatin)

Results

No trials comparing Mevacor® and ZYPITAMAG are available at this time.

Other Key Points

Unlike Mevacor®, ZYPITAMAG has no effect on prothrombin time (PT) or international normalized ratio (INR) when co-administered with warfarin. However, PT and INR should still be routinely monitored by your doctor.

Unlike Mevacor®, ZYPITAMAG can be used in combination with antiretroviral therapies (ARTs) such as atazanavir, darunavir/ritonavir, and lopinavir/ritonavir.

Unlike Mevacor®, ZYPITAMAG does not require restrictions for grapefruit products.

Unlike Mevacor®, ZYPITAMAG has no dose restrictions or limitations when use with certain antifungals such as itraconazole.

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Pravachol®, Lipitor®, Crestor®, Zocor®, and Mevacor® are the property of their respective owners.

IMPORTANT SAFETY INFORMATION for ZYPITAMAG™ (pitavastatin) tablets

Who should NOT take ZYPITAMAG?

ZYPITAMAG is not right for everyone. Do not take ZYPITAMAG if:

  • You have a known allergy to ZYPITAMAG or any of its ingredients.
  • You have active liver problems, including some abnormal liver test results.
  • You are nursing, pregnant or may become pregnant, as it may harm the baby.
  • You are currently taking cyclosporine or gemfibrozil.

What is the most important information I should know and talk to my doctor about?

  • Call your healthcare provider or get help right away if you experience any symptoms of an allergic reaction, such as rash, itching, or hives.
  • Muscle problems may be an early sign of rare, serious conditions. Tell your doctor right away if you have any unexplained muscle pain, weakness, or tenderness, particularly if accompanied by malaise or fever, or if these muscle signs or symptoms persist after discontinuing ZYPITAMAG.
  • Serious liver problems have been reported rarely in patients taking statins, including pitavastatin. Your doctor should do liver tests before you start, and if you have symptoms of liver problems while you are taking ZYPITAMAG. Tell your healthcare provider right away if you feel more tired than usual, have a loss of appetite, upper belly pain, dark-colored urine, or yellowing of the skin or eyes.
  • Tell your doctor about all your medical conditions and medications you take including nonprescription medicines, vitamins, or herbal supplements.
  • Increases in blood sugar levels have been reported with statins, including pitavastatin.
  • Tell your doctor about your alcohol use.

What are the most common side effects of ZYPITAMAG?

The most common side effects of ZYPITAMAG in clinical studies were:

  • Back pain
  • Constipation
  • Diarrhea
  • Muscle pain
  • Pain in the legs or arms

This is not a complete list of side effects. Talk to your healthcare provider for more information.

You are encouraged to report negative side effects of all drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

How should I store and take ZYPITAMAG?

  • Store ZYPITAMAG tablets at room temperature, in a dry place, and out of the reach of children.
  • ZYPITAMAG can be taken at any time of day, with or without food.
  • Swallow the tablet whole. Do not split, crush, dissolve, or chew.

Other important information I should know about ZYPITAMAG.

  • ZYPITAMAG has not been studied to evaluate its effect on reducing heart-related disease or death.
  • ZYPITAMAG is available by prescription only.

For additional information, please see the full Prescribing Information.

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